Using minoxidil is a surefire way to help with hair loss. But did you know that how you apply it can make a big difference? We asked experts and found some genius tips for how to use minoxidil that will make the drug perform even better for thicker, fuller hair faster. Plus, if you’ve tried minoxidil in the past and haven’t seen any results, we have some insight into why. Below, minoxidil hacks and application tricks so you can get the most out of the powerful hair regrowth ingredient.
How to use minoxidil the right way
“One of the most common things I hear in my clinic is, ‘I tried minoxidil/Rogaine, but it didn’t work,’” says Alan J. Bauman, MD, ABHRS, IAHRS, FISHRS, Founder, CEO & Medical Director of Bauman Medical Hair Transplant & Hair Loss Treatment Center. Thankfully, there are a few ways to use minoxidil to see the best results. Keep scrolling to see them.
Apply minoxidil on a dry scalp and hair
“Make sure your scalp and hair are completely dry before applying the solution,” says Mandy Buechner, a trichologist and CEO of Thairapy Wellness Center. “This helps ensure proper absorption and reduces the risk of dilution or ineffective application.” When applying, also gently massage the treatment onto the scalp to help it absorb and stimulate hair follicles.
The timing of when you use minoxidil matters
“Minoxidil is usually applied twice daily—morning and evening,” says Buechner. She suggests trying to apply it at least 12 hours apart for the best results. “Pick times that fit easily into your daily routine to maintain consistency.”
Follow the product’s application instructions
Buechner advises using the amount specified in the product instructions (typically 1 mL per application). “Avoid applying more than directed, as this doesn’t enhance effectiveness and may increase the risk of side effects.”
Avoid using other products immediately after application
“Allow minoxidil to dry completely before applying other hair products or before going to bed,” notes Buechner. “Applying other products too soon can interfere with minoxidil’s absorption.”
Clean your hands and the applicator after applying minoxidil
“Wash your hands thoroughly after applying minoxidil to avoid transferring it to other parts of your body or to other people,” cautions Buechner. “If using a dropper or applicator, clean it regularly to prevent contamination.”
Keep an eye out for any side effects
“Watch for any adverse reactions, such as scalp irritation or unwanted facial hair growth,” says Buechner. “If you experience severe side effects like an allergic reaction or have concerns, consult your healthcare provider.”
Stay consistent with minoxidil application
“Consistency is crucial,” says Buechner. “Apply minoxidil daily and at the same time each day to maintain hair growth and steady levels of the medication.”
Patience is key when using minoxidil
Buechner says it’s important to know that hair growth can take several months to become noticeable. Also, “during the initial phase, some users may experience increased hair shedding, which is a normal part of the process.”
4 minoxidil hacks that can supercharge hair growth in women
1. Use a dermaroller before applying minoxidil
Microneedling is commonly done on the face as a method for creating micro-injuries in the skin that help with the absorption of skin care products. That same methodology can be used on the scalp to help minoxidil penetrate deeper for better hair growth results.
“Dermarolling/microneedling the scalp before applying minoxidil creates microtrauma that activates the body’s natural healing pathways, increases blood flow, and creates microchannels in the skin that may enhance the absorption of minoxidil or other topically applied products,” says Dr. Bauman. Indeed, studies have found that the use of microneedling and minoxidil together is an effective treatment for stimulating hair growth.
But there are risks of microneedling/dermarolling at home, cautions Dr. Bauman. He says these include “over-traumatizing” the scalp (too deep, too often, worn-out/damaged tools), which could exacerbate hair loss, infection (from using unclean/non-sterile techniques), pain, and bleeding or bruising.
“It is important to note that devices like the derma-pens sold on Amazon are notorious for being quickly contaminated with blood, dirt or debris, are likely not sterile, and can often cause more damage to the skin and scalp than improve hair,” he warns. So when doing this technique, it’s key to properly sterilize the roller in between uses.
For a how-to video and more on the benefits, watch this TikTok from dermatologist Neera Nathan, MD.
Pro tip: As dermatologist Shereene Idriss, MD mentions in this TikTok she posted, use men’s 5% minoxidil over the women’s version. That’s because it can cost less but works exactly the same.
2. Pair minoxidil with retinol
If you’ve tried minoxidil in the past and didn’t notice any results (even after using it consistently), there’s an interesting reason as to why this may have happened. For minoxidil to work properly, it needs to be converted to its active form, minoxidil sulfate. And this is done by coming into contact with an enzyme called sulfotransferase on the scalp. But if levels of the enzyme are low, then minoxidil will not be effective. Applying tretinoin can enhance this conversion and improve minoxidil absorption.
Enter: Retinol, but specifically tretinoin, which is only offered as a prescription. This form of retinol can be used topically on the scalp (before minoxidil) and helps raise sulfotransferase levels to boost the efficacy of minoxidil. In fact, one study reports that levels were raised after 5 days of using tretinoin.
“It’s important to note that because of one’s unique DNA, treatments may not work the same for everyone. Through TrichoTest—a DNA test—we can predict whether minoxidil may be effective for you,” adds Dr. Bauman. “New information on the genetic variants can help predict your response to oral or topical minoxidil as a hair growth treatment.”
Tip: You can try using an OTC version of retinol on the scalp first to see if it helps with hair growth, as recommended by dermatologist @drcharlesmd1 in this TikTok video.
Good to know: Taking aspirin can interfere with minoxidil’s efficacy
Dermatologist Sam Ellis, MD gives a warning in this TikTok video that taking aspirin daily can also hinder the effectiveness of minoxidil. That’s because it interferes with the levels of the aforementioned enzyme sulfotransferase.
3. Wash hair with these types of shampoo when using minoxidil
Sudsing up with a shampoo that contains ketoconazole or zinc pyrithione can help minoxidil perform better, as touted by dermatologist Jenny Liu, MD in this TikTok. Why? “These ingredients have anti-inflammatory and antifungal properties, which help maintain a healthy scalp environment conducive to hair growth,” says Dr. Bauman. “Ketoconazole, in particular, is also known for its mild anti-androgen effects. Note: The androgen dihydrotestosterone (DHT) is a known disruptor of hair growth, he says.
Two shampoos that we like and contain these ingredients are Nizoral Anti-Dandruff Shampoo and Dove Dermacare Scalp Anti-Dandruff Shampoo. “However, ketoconazole shampoos in particular are notoriously harsh on the hair and scalp and can leave the hair dry, dull, and generally in poor aesthetic condition. So there’s a huge tradeoff,” notes Dr. Bauman. “Also, it is inconvenient for many people to allow the recommended time [10 minutes] for the proper absorption of ketoconazole into the scalp/follicles.”
4. Apply minoxidil to brows for thicker arches
Dealing with thinning hair on your brows too? The good news is that you can apply the treatment to them as well to boost hair growth since the ingredient works exactly the same no matter where it is applied. “It should be applied carefully—do not get it in your eye!—and a compounded version is recommended for better absorption and a more comfortable experience,” says Dr. Bauman. He also notes that “it’s important to remember that minoxidil use is a long-term commitment. “And [it] should be undertaken with the guidance of a board-certified hair restoration physician.”
See this TikTok from Dr. Nathan for her tips and tricks for using the ingredient on eyebrows.