Amy Schumer is getting candid about her unpleasant experience on the weight loss drug Ozempic. The comedian and actress, 43, recently revealed that she quickly lost 30 pounds. However, the side effects were unbearable and ultimately forced her to stop using it. While many people see positive results on GLP-1 medications, others like Schumer experience severe side effects. We spoke with healthcare professionals to break down how common these reactions are, who might want to avoid GLP-1 drugs and how to minimize side effects if you do take it.
Amy Schumer’s experience on the weight loss drug Ozempic
Schumer first revealed her struggles with Ozempic in June 2023. She explained that the side effects left her unable to play with her son. “I was so skinny, and he’s throwing a ball at me and [I couldn’t play],” she said on Watch What Happens Live with Andy Cohen.
During a January 29 appearance on The Howard Stern Show, Schumer elaborated on how while the weight loss results were impressive, Ozempic made her so sick that she felt like she was “shriveling away.” “I lost 30 pounds so quick. I looked great, but I couldn’t lift my head off the pillow. So what’s the point?” she said. “I was bedridden. I was like, vomiting—and then you have no energy.” She ultimately quit the GLP-1 drug.
Schumer also speculated that her extreme nausea resulted from a genetic predisposition. “I have this gene, GDF15, which makes you extremely prone to nausea, which is why I was so sick during my pregnancy,” she said.
How common are severe side effects from Ozempic?
Ozempic (semaglutide) is FDA-approved for type 2 diabetes but is widely used off-label for weight loss. “Nausea is one of the most frequently reported side effects of Ozempic and other GLP-1 receptor agonists,” says Jennifer Habashy, NMD, MS, Assistant Medical Director at Claya. It occurs in roughly 20 to 45 percent of patients, she continues, especially at the beginning of treatment or during dosage increases. Other common side effects include vomiting, constipation and diarrhea.
Many users experience mild discomfort that subsides over time. “Severe negative side effects are rare, around 4 percent with Ozempic or Wegovy and less than that with Zepbound,” says Eleanor Yusupov, DO, Assistant Professor at NYIT College Of Osteopathic Medicine. In these cases, extreme reactions may lead to malnutrition, dehydration or overall intolerance, according to Dr. Habashy.
Others, like Schumer, may have a heightened sensitivity to GLP-1 weight loss drugs due to genetic factors. “The GDF15 protein that Schumer mentioned, is produced by different cells in the body. [It] plays a role in nausea and vomiting during pregnancy and other conditions,” says Dr. Yusupov.
However, this shouldn’t be cause for alarm for most GLP-1 users. “No genetic testing is recommended before starting weight loss medications,” she clarifies.
Who should avoid GLP-1 medications like Ozempic?
“For most people, Ozempic and Wegovy are considered safe when prescribed and monitored by a healthcare provider,” says Dr. Habashy. However, you should always consult with your doctor if you have any concerns or are experiencing severe side effects.
“I recommend that people let their doctor know if they ever have serious stomach, pancreas, kidney or gallbladder problems,” says Dr. Yusupov. “GLP1 medications are not for people planning a pregnancy or those with a history of thyroid cancer.” Additionally, she encourages sharing any upcoming surgery or procedures, which may warrant certain precautions.
How to reduce the risk of side effects on Ozempic
“To minimize side effects, it is best to start with the lowest dose and gradually increase as tolerated,” advises Dr. Habashy. This helps your body adjust to the medication.
“Taking the injection on a full stomach, staying hydrated and eating smaller, more frequent meals can help manage nausea,” adds Dr. Habashy. Water, in particular, can support digestion. You should also try to avoid fried or fatty foods, as well as eating within three to four hours of sleeping, adds Dr. Yusupov.
Remember that, unlike Schumer, most patients experience only mild gastrointestinal symptoms. You can manage these over time. “If symptoms persist despite dietary and lifestyle modifications or become severe, medication needs to be stopped,” says Dr. Yusupov.
Schumer’s take on weight loss drugs in Hollywood
Schumer has been vocal about celebrities hiding their use of Ozempic for weight loss. “Everyone has been lying saying, ‘Oh, smaller portions.’ Like, shut the f— up. You are on Ozempic or one of those things or you got work done,” she said.
The Life & Beth star noted that she’s always been transparent about her health choices, including previously undergoing liposuction. But when it comes to lasting weight loss results, are GLP-1 medications or lifestyle changes more important?
“Making lifestyle changes is crucial whether or not people take weight loss medications,” says Dr. Yusupov. “GLP1 medications are highly effective. However, when they are stopped, people will have the best chance to keep the weight off if they have built healthy habits.” This includes managed stress, adequate sleep, a nutritious diet and an active lifestyle.
“Studies show that individuals who rely solely on medication often regain weight once they stop treatment, whereas those who incorporate lasting dietary and exercise habits are more likely to maintain their results,” adds Dr. Habashy.
While Schumer ultimately stopped taking Ozempic due to side effects, the medication continues to be a popular and effective weight-loss tool for many. If you’re considering taking it, talk to your doctor to better understand the potential risks and find the best approach for you.
This content is not a substitute for professional medical advice or diagnosis. Always consult your physician before pursuing any treatment plan.